Exosomal microRNAs in liquid biopsies: future biomarkers for prostate cancer

Marco Giallombardo, Pablo Reclusa Asiain, Camps, Marco Giallombardo, Anna Valentino, Patrick Pauwels, Rafael Sirera, Pablo Reclusa, Christian Rolfo, Crispi

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Prostate cancer is the second most diagnosed cancer in males in the world. Plasma quantification of prostate-specific antigen substantially improved the early detection of prostate cancer, but still lacks the required specificity. Clinical management of prostate cancer needs advances in the development of new non-invasive biomarkers, ameliorating current diagnosis and prognosis and guiding therapeutic decisions. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the post-transcriptional level. These miRNAs are expressed in the cells and are also present in cell-derived extracellular vesicles such as exosomes. Exosomes have been shown to act as mediators for cell to cell communication because of the regulatory functions of their content. High levels of exosomes are found in several body fluids from cancer patients and could be a potential source of non-invasive biomarkers. In this review, we summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer.
Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalCLINICAL & TRANSLATIONAL ONCOLOGY.
Volume19
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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