Evidence for a novel cytoplasmic processing event in ribosome maturation in the sea urchin Paracentrotus lividus.

Rainero Barbieri, Daniele Bellavia

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    In this paper we demonstrate the existence of a cytoplasmic processing step, never before described, involving both the pre-ribosomal subunits in the sea urchin Paracentrotus lividus. Northern-blot hybridization, primer extension, S1 mapping experiments and in situ hybridizations allowed us to demonstrate that cytoplasmic processed particles are successively re-imported into the nucleus where maturation of their RNAs is completed prior to being exported to the cytoplasm. Our findings lead to the proposal of a new model of ribosome maturation and shuttling.
    Original languageEnglish
    Pages (from-to)1871-1879
    Number of pages9
    JournalCellular and Molecular Life Sciences
    Publication statusPublished - 2010

    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

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