Evaluating The Stability of Pharmacophore Features Using Molecular Dynamic Simulations

Ugo Perricone, Stefan Boresch, Thierry Langer, Marcus Wieder, Thomas Seidel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Molecular dynamics simulations of twelve protein-ligand systems were used to derive a single, structure based pharmacophore model for each system. These merged models combine the information from the initial experimental structure and from all snapshots saved during the simulation. We compared the merged pharmacophore models with the corresponding PDB pharmacophore models, i.e., the static models generated from an experimental structure in the usual manner. The frequency of individual features, of feature types and the occurrence of features not present in the static model derived from the experimental structure were analyzed. We observed both pharmacophore features not visible in the traditional approach, as well as features which disappeared rapidly during the molecular dynamics simulations and which may well be artifacts of the initial PDB structure-derived pharmacophore model. Our approach helps mitigate the sensitivity of structure based pharmacophore models to the single set of coordinates present in the experimental structure. Further, the frequency with which specific features occur during the MD simulation may aid in ranking the importance of individual features.
Original languageEnglish
Pages (from-to)-
Number of pages5
JournalBiochemical and Biophysical Research Communications
Publication statusPublished - 2016

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Molecular Dynamics Simulation
Molecular dynamics
Theoretical Models
Computer simulation
Artifacts
Ligands
Proteins

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Cell Biology
  • Molecular Biology
  • Biochemistry

Cite this

Evaluating The Stability of Pharmacophore Features Using Molecular Dynamic Simulations. / Perricone, Ugo; Boresch, Stefan; Langer, Thierry; Wieder, Marcus; Seidel, Thomas.

In: Biochemical and Biophysical Research Communications, 2016, p. -.

Research output: Contribution to journalArticle

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