Estimating brain connectivity when few data points are available: Perspectives and limitations

Yuri Antonacci, Jlenia Toppi, Stefano Caschera, Alessandra Anzolin, Yuri Antonacci, Laura Astolfi, Donatella Mattia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Citations (Scopus)

Abstract

Methods based on the use of multivariate autoregressive modeling (MVAR) have proved to be an accurate and flexible tool for the estimation of brain functional connectivity. The multivariate approach, however, implies the use of a model whose complexity (in terms of number of parameters) increases quadratically with the number of signals included in the problem. This can often lead to an underdetermined problem and to the condition of multicollinearity. The aim of this paper is to introduce and test an approach based on Ridge Regression combined with a modified version of the statistics usually adopted for these methods, to broaden the estimation of brain connectivity to those conditions in which current methods fail, due to the lack of enough data points. We tested the performances of this new approach, in comparison with the classical approach based on ordinary least squares (OLS), by means of a simulation study implementing different ground-truth networks, under different network sizes and different levels of data points. Simulation results showed that the new approach provides better performances, in terms of accuracy of the parameters estimation and false positives/false negatives rates, in all conditions related to a low data points/model dimension ratio, and may thus be exploited to estimate and validate estimated patterns at single-trial level or when short time data segments are available.
Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Pages4351-4354
Number of pages4
Publication statusPublished - 2017

Publication series

NameIEEE ENGINEERING IN MEDICINE AND BIOLOGY ... ANNUAL CONFERENCE PROCEEDINGS

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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