Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery

Laura Modica De Mohac, Maria De Fátima Pina, Maria De Fátima Pina, Bahijja Tolulope Raimi-Abraham, Laura Modica De Mohac, Alison Veronica Keating, Laura Modica De Mohac, Maria De Fátima Pina

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
Original languageEnglish
Pages (from-to)7-
Number of pages10
JournalPharmaceutics
Volume11
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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