End-to-end tests using alanine dosimetry in scanned proton beams

Antonio Carlino, Maurizio Marrale, Kragl, Carlino, Gouldstone, Stock, Traneus, Vatnitsky, Palmans

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis) phantoms were used for end-to-end tests at MedAustron. The phantoms were equipped with alanine detectors, radiochromic films and ionization chambers. The correction for the 'quenching' effect of alanine pellets was implemented in the Monte Carlo platform of the evaluation version of RayStation TPS. During the end-to-end tests, the phantoms were transferred through the workflow like real patients to simulate the entire clinical workflow: immobilization, imaging, treatment planning and dose delivery. Different clinical scenarios of increasing complexity were simulated: delivery of a single beam, two oblique beams without and with range shifter. In addition to the dose comparison in the plastic phantoms the dose obtained from alanine pellet readings was compared with the dose determined with the Farmer ionization chamber in water. A consistent systematic deviation of about 2% was found between alanine dosimetry and the ionization chamber dosimetry in water and plastic materials. Acceptable agreement of planned and delivered doses was observed together with consistent and reproducible results of the end-to-end testing performed with different dosimetric techniques (alanine detectors, ionization chambers and EBT3 radiochromic films). The results confirmed the adequate implementation and integration of the new PBS technology at MedAustron. This work demonstrates that alanine pellets are suitable detectors for end-to-end tests in proton beam therapy and the developed procedures with customized anthropomorphic phantoms can be used to support implementation of PBS technology in clinical practice.
Original languageEnglish
Pages (from-to)055001-
Number of pages17
JournalPhysics in Medicine and Biology
Volume63
Publication statusPublished - 2018

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Alanine
Protons
Workflow
Plastics
Proton Therapy
Technology
Synchrotrons
Water
Pelvis
Immobilization
Reading
Head
Therapeutics

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

End-to-end tests using alanine dosimetry in scanned proton beams. / Carlino, Antonio; Marrale, Maurizio; Kragl; Carlino; Gouldstone; Stock; Traneus; Vatnitsky; Palmans.

In: Physics in Medicine and Biology, Vol. 63, 2018, p. 055001-.

Research output: Contribution to journalArticle

Carlino, A, Marrale, M, Kragl, Carlino, Gouldstone, Stock, Traneus, Vatnitsky & Palmans 2018, 'End-to-end tests using alanine dosimetry in scanned proton beams', Physics in Medicine and Biology, vol. 63, pp. 055001-.
Carlino, Antonio ; Marrale, Maurizio ; Kragl ; Carlino ; Gouldstone ; Stock ; Traneus ; Vatnitsky ; Palmans. / End-to-end tests using alanine dosimetry in scanned proton beams. In: Physics in Medicine and Biology. 2018 ; Vol. 63. pp. 055001-.
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AU - Marrale, Maurizio

AU - Kragl, null

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AU - Stock, null

AU - Traneus, null

AU - Vatnitsky, null

AU - Palmans, null

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N2 - This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis) phantoms were used for end-to-end tests at MedAustron. The phantoms were equipped with alanine detectors, radiochromic films and ionization chambers. The correction for the 'quenching' effect of alanine pellets was implemented in the Monte Carlo platform of the evaluation version of RayStation TPS. During the end-to-end tests, the phantoms were transferred through the workflow like real patients to simulate the entire clinical workflow: immobilization, imaging, treatment planning and dose delivery. Different clinical scenarios of increasing complexity were simulated: delivery of a single beam, two oblique beams without and with range shifter. In addition to the dose comparison in the plastic phantoms the dose obtained from alanine pellet readings was compared with the dose determined with the Farmer ionization chamber in water. A consistent systematic deviation of about 2% was found between alanine dosimetry and the ionization chamber dosimetry in water and plastic materials. Acceptable agreement of planned and delivered doses was observed together with consistent and reproducible results of the end-to-end testing performed with different dosimetric techniques (alanine detectors, ionization chambers and EBT3 radiochromic films). The results confirmed the adequate implementation and integration of the new PBS technology at MedAustron. This work demonstrates that alanine pellets are suitable detectors for end-to-end tests in proton beam therapy and the developed procedures with customized anthropomorphic phantoms can be used to support implementation of PBS technology in clinical practice.

AB - This paper describes end-to-end test procedures as the last fundamental step of medical commissioning before starting clinical operation of the MedAustron synchrotron-based pencil beam scanning (PBS) therapy facility with protons. One in-house homogeneous phantom and two anthropomorphic heterogeneous (head and pelvis) phantoms were used for end-to-end tests at MedAustron. The phantoms were equipped with alanine detectors, radiochromic films and ionization chambers. The correction for the 'quenching' effect of alanine pellets was implemented in the Monte Carlo platform of the evaluation version of RayStation TPS. During the end-to-end tests, the phantoms were transferred through the workflow like real patients to simulate the entire clinical workflow: immobilization, imaging, treatment planning and dose delivery. Different clinical scenarios of increasing complexity were simulated: delivery of a single beam, two oblique beams without and with range shifter. In addition to the dose comparison in the plastic phantoms the dose obtained from alanine pellet readings was compared with the dose determined with the Farmer ionization chamber in water. A consistent systematic deviation of about 2% was found between alanine dosimetry and the ionization chamber dosimetry in water and plastic materials. Acceptable agreement of planned and delivered doses was observed together with consistent and reproducible results of the end-to-end testing performed with different dosimetric techniques (alanine detectors, ionization chambers and EBT3 radiochromic films). The results confirmed the adequate implementation and integration of the new PBS technology at MedAustron. This work demonstrates that alanine pellets are suitable detectors for end-to-end tests in proton beam therapy and the developed procedures with customized anthropomorphic phantoms can be used to support implementation of PBS technology in clinical practice.

KW - Computer-Assisted; Synchrotrons; Phantoms

KW - Imaging; Protons; Radiological and Ultrasound Technology; Radiology

KW - Nuclear Medicine and Imaging

KW - alanine; anthropomorphic phantoms; audit; dosimetry; end to end test; protons; Alanine; Head; Humans; Monte Carlo Method; Pelvis; Radiation Dosage; Radiometry; Radiotherapy Planning

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UR - http://iopscience.iop.org/article/10.1088/1361-6560/aaac23/pdf

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SP - 055001-

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

ER -