EGFR inhibition in NSCLC: New findings…. and opened questions?

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Abstract

The targeted inhibition of epidermal growth factor receptor (EGFR) has represented a milestone in the treatment of lung cancer. Several studies convincingly and consistently demonstrated a significant superiority of EGFR-TKIs over standard platinum-chemotherapy in EGFR-mutated NSCLC patients, leading to the sequential approval of gefitinib, erlotinib and afatinib as new standard first-line clinical treatment. To date we are witnessing a second revolution in the management of EGFR-positive NSCLC thanks to the development of new treatment strategies aiming to overcome acquired resistance to TKIs and ultimately improve patients’ outcomes. In this review we summarize the most important recent findings regarding EGFR-inhibition in NSCLC, highlighting the current unsolved questions on the selection of the best TKI in first-line, which therapy can be combined with upfront EGFR-TKIs, how to overcome acquired resistance, and which are the clinical applications of liquid biopsy.
Original languageEnglish
Pages (from-to)126-135
Number of pages10
JournalCRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume112
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Hematology
  • Oncology

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