Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalermin for intramuscular use in peripheral neuropathies

Dalila Scaturro, Giulia Letizia Mauro, Michele Vecchio, Lorenza Lauricella, Michele Maria Vecchio, Sofia Tomasello

Research output: Contribution to journalArticle

Abstract

Peripheral neuropathies are frequently encourtered in clinical practice and are assiociated with a major impairment in quality of life . Howewvwr, their management reamans poor, and current therapies are often burdened with major side effects and can present poor efficacy on pain and functionality. Therefore, it has been suggested that the combination of two or more different drugs may improve analgesis efficacy and reduce side effects. Tricortin 1000 is formulated with 12 mg of Brain cortex phospholipid liposomes + 1000 microgrammi of Cyanocobalamin injectable (PL+ CNCb1) for intramuscolar use and is indicated in the tratment of poly-algo-neuropathic syndromes. This combination exerts a marked neurotrophic action by promoting the syntesis of endogenous phospholipids; moreover the peculiar formulation optimized the delivery of CNCb1 wich has analgesis and neurotrophic action. This paper discusses the pharmacotherapy of peripheral neuropathies, including low back pain, neck pain, post herpetic neuropathy (PHN) and focuses on the fixed dose combination PL+CNCb1 ckinical efficacy in association with other treatment or in monotherapy.
Original languageEnglish
Pages (from-to)455-463
Number of pages9
JournalMinerva Medica
Volume110
Publication statusPublished - 2019

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Peripheral Nervous System Diseases
Liposomes
Phospholipids
Neck Pain
Vitamin B 12
Low Back Pain
Quality of Life
Drug Therapy
Pain
Injections
Brain
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Efficacy and tolerability of a fixed dose combination of cortex phospholipid liposomes and cyanocobalermin for intramuscular use in peripheral neuropathies. / Scaturro, Dalila; Letizia Mauro, Giulia; Vecchio, Michele; Lauricella, Lorenza; Vecchio, Michele Maria; Tomasello, Sofia.

In: Minerva Medica, Vol. 110, 2019, p. 455-463.

Research output: Contribution to journalArticle

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AU - Vecchio, Michele Maria

AU - Tomasello, Sofia

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