EFFICACIA NELLA PRATICA CLINICA DI UN SUPPLEMENTO A BASE DI GLUCOSAMINA SOLFATO(GS), CONDROITINA SOLFATO (CS), COLLAGENE IDROLIZZATO DI TIPO B, ACIDO IALURONICO IDROLIZZATO E L-CARNITINA IN SOGGETTI CON OSTEOARTROSI DEL GINOCCHIO

Research output: Contribution to journalArticlepeer-review

Abstract

[automatically translated] Aim: Osteoarthritis (OA) is a degeneration of articular cartilage. four components of the cartilage structure, glucosamine, chondroitin collagen type II and hyaluronic acid are available in a food supplements. It Has Been Claimed That they reduce the pain of OA and help rebuild cartilage in patients with early OA. Methods: A multicentre, randomized, double-blind controlled study ascorbic acid was any carried out in patients with osteoarthritis of the knee. The purpose of the study was to evaluate the effectiveness of a food supplement sachets containing glucosamine sulfate (500 mg), chondroitin sulfate (400 mg), hydrolyzed collagen and hyaluronic acid mixture chicks II (300 mg), L-carnitine fumarate (345 mg ). One hundred twenty patients suffering from osteoarthritis of the knee were randomized into 2 groups. Sixty randomized patients in group A received a single sachet daily for 60 days. Sixty randomized patients in group B received placebo daily sachet containing 1 gram of ascorbic acid. Clinical follow-up was performed at 2, 4, 8, and 12 weeks. The degree of knee pain was Assessed using a VAS score. WOMAC score, and Lequesne index KOOS scales were used to assess the knee injury and OA outcome score. Results: The reduction of VAS score from baseline through week 12 was statistically significant only in group A (P <0.05). WOMAC and KOOS scales Showed imporovement only in groupo A for pain at week 4, for stiffness and difficulty in carrying out normal physical activities at week 8. Also the Lequesne index Showed an improvement Exclusively in group A, after week 4.Conclusion:
Original languageItalian
Pages (from-to)1-9
Number of pages9
JournalMinerva Ortopedica e Traumatologica
Volume63
Publication statusPublished - 2012

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