EFFETTI DELL'ALLOPURINOLO SUL DECLINO DEL FILTRATO GLOMERULARE IN PAZIENTI IPERTESICON INSUFFICIENZA RENALE CRONICA

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Abstract

[automatically translated] The asymptomatic hyperuricaemia role as a factor capable of promoting independently the progression of chronic kidney disease remains controversial. In addition, studies aimed at evaluating the influence of the therapy on ipouricemizzante evolution of chronic kidney disease are few and have yielded conflicting results. The aim of this observational study was to retrospectively analyze the effect of treatment with allopurinol, the decline of glomerular filtration rate in hypertensive patients with chronic renal insufficiency moderately to severely. Were therefore selected 22 patients treated with allopurinol (A) (100-300 mg / day) were compared with 44 subjects not treated with ipouricemizzanti (B) and paired with the group in therapy with allopurinol regard to filtrate estimated glomerular (eGFR), age, sex, and blood pressure. After a median of 16 months follow-up, no difference was observed between the two groups with regard to both the rapidity of the decline of eGFR (A: -6.8 ± 11.6 ml / min / 1.73 m2; B: -4.2 ± 9.3 ml /min/1.73 m2), both as regards the percentage of individuals who experienced a greater reduction of the distribution median eGFR of this parameter (a: 59%; B: 41%; p = 0:16). The multiple logistic regression analysis confirmed, even after adjustment for potential confounding factors, the ' dell'allopurinolo absence of a significant impact on the decline of glomerular filtration rate during the observation period and showed that the variables independently associated with the decrease in GFR were the presence of proteinuria and GFR at baseline. Our data do not support the results of previous studies that showed a nephroprotective dell'allopurinolo effect. More and more extensive type of randomized and controlled studies are needed to understand if pharmacologically treat subjects with asymptomatic hyperuricemia in order to preserve renal function. allopurinol on the decline of glomerular filtration rate during the observation period and showed that the variables independently associated with the decrease in GFR were the presence of proteinuria and GFR at baseline. Our data do not support the results of previous studies that showed a nephroprotective dell'allopurinolo effect. More and more extensive type of randomized and controlled studies are needed to understand if pharmacologically treat subjects with asymptomatic hyperuricemia in order to preserve renal function. allopurinol on the decline of glomerular filtration rate during the observation period and showed that the variables independently associated with the decrease in GFR were the presence of proteinuria and GFR at baseline. Our data do not support the results of previous studies that showed a nephroprotective dell'allopurinolo effect. More and more extensive type of randomized and controlled studies are needed to understand if pharmacologically treat subjects with asymptomatic hyperuricemia in order to preserve renal function.
Original languageItalian
Pages (from-to)110-110
Number of pages1
JournalIPERTENSIONE E PREVENZIONE CARDIOVASCOLARE
Volume20
Publication statusPublished - 2013

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