Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C

Stefania Grimaudo, Calogero Camma', Antonio Craxi, Paolo Caviglia, David Booth, Mario Rizzetto, Roberto Gambino, Chiara Rosso, Reynold Leung, Federico Salomone, Elisabetta Bugianesi, Maria Lorena Abate, Antonina Smedile, Jacob George

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.
Original languageEnglish
Pages (from-to)311-317.e1
Number of pages22
JournalClinical Gastroenterology and Hepatology
Volume11
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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