Aim: To evaluate retrospectively the effects of allopurinol treatment on renal function decline in non-gouty hypertensive patients with moderate-to-severe CKD.Methods: We selected 22 patients treated with allopurinol (A) (100–300 mg/die) that were compared with 44 subjects not treated with this drug (B), matched with A for estimatedglomerular filtration rate (eGFR), age, gender andblood pressure values.Results: After a mean follow-up period of 16 months no significant difference was observed between the two groups regarding eGFR decline (A: -6.8 ± 11.6 ml/min/1.73 m2; B: -4.2 ± 9.3 ml/min/1.73 m2). Furthermore, the percentageof subjects with a value of eGFR reduction abovethe median was not significantly different in the two groups (A: 59 %; B: 41 %; p = 0.16). The absence of a significant effect of allopurinol on the eGFR decline was confirmed by the multiple logistic regression analysis, where the variablesassociated with a greater eGFR reduction were theproteinuria and the baseline value of GFR.Conclusions: Our findings are in disagreement with previous studies showing a nephroprotective effect of allopurinol.Further studies, with a randomized controlleddesign, are needed to understand whether or not pharmacological treatment of asymptomatic hyperuricemia may preserve renal function.
|Number of pages||2|
|Publication status||Published - 2013|
Vaccaro, F., Cottone, S., Mule', G., Ocello, A., Castiglia, A., D'Ignoto, F., Vario, M. G., Morreale, M., & Bellavia, T. (2013). EFFECTS OF ALLOPURINOL ON RENAL FUNCTION DECLINE IN HYPERTENSIVE PATIENTS WITH CHRONIC KIDNEY DISEASES. 185-186.