EFFECTS OF ALLOPURINOL ON RENAL FUNCTION DECLINE IN HYPERTENSIVE PATIENTS WITH CHRONIC KIDNEY DISEASES

Francesco Vaccaro, Santina Cottone, Giuseppe Mule', Alessandra Ocello, Antonella Castiglia, Francesco D'Ignoto, Maria Giovanna Vario, Massimiliano Morreale, Tania Bellavia

Research output: Contribution to conferenceOther

Abstract

Aim: To evaluate retrospectively the effects of allopurinol treatment on renal function decline in non-gouty hypertensive patients with moderate-to-severe CKD.Methods: We selected 22 patients treated with allopurinol (A) (100–300 mg/die) that were compared with 44 subjects not treated with this drug (B), matched with A for estimatedglomerular filtration rate (eGFR), age, gender andblood pressure values.Results: After a mean follow-up period of 16 months no significant difference was observed between the two groups regarding eGFR decline (A: -6.8 ± 11.6 ml/min/1.73 m2; B: -4.2 ± 9.3 ml/min/1.73 m2). Furthermore, the percentageof subjects with a value of eGFR reduction abovethe median was not significantly different in the two groups (A: 59 %; B: 41 %; p = 0.16). The absence of a significant effect of allopurinol on the eGFR decline was confirmed by the multiple logistic regression analysis, where the variablesassociated with a greater eGFR reduction were theproteinuria and the baseline value of GFR.Conclusions: Our findings are in disagreement with previous studies showing a nephroprotective effect of allopurinol.Further studies, with a randomized controlleddesign, are needed to understand whether or not pharmacological treatment of asymptomatic hyperuricemia may preserve renal function.
Original languageEnglish
Pages185-186
Number of pages2
Publication statusPublished - 2013

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    Vaccaro, F., Cottone, S., Mule', G., Ocello, A., Castiglia, A., D'Ignoto, F., Vario, M. G., Morreale, M., & Bellavia, T. (2013). EFFECTS OF ALLOPURINOL ON RENAL FUNCTION DECLINE IN HYPERTENSIVE PATIENTS WITH CHRONIC KIDNEY DISEASES. 185-186.