Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity

Fabio Caradonna, Alessandro Perez, Mabel Nogueras, Lucas Costa, Jorge P. Castagnino, Julián G. Chamorro, Omar Aidar, Mabel Visca, Ana Frías, Rosa M. Musella, Gabriela F. De Larrañaga

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1), and glutathione S-transferase mu 1] with antituberculosis drug-induced hepatotoxicity (ATDH). We also investigated the potential gene-gene and gene-environment interactions as well as their association with ATDH development in a population of hospitalized TB patients from Buenos Aires.
Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalPharmacogenetics and Genomics
Volume27
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity'. Together they form a unique fingerprint.

Cite this