Effect of Fibrin Sealant on Seroma Formation Post-Incisional Hernia Repair

Beatrice D'Orazio, Sebastiano Bonventre, Bianca Maria Cudia, Girolamo Geraci, Fausto Famà, Gaetano Di Vita, Carmelo Sciume, Giovanni Corbo, Gloria Maria Terranova

Research output: Contribution to journalArticlepeer-review


Background: Development of seroma after incisional hernia repair is a common complication. Our study aims to compare the outcomes of sublay incisional hernia repairs with or without spray instillation of fibrin glue. Methods: We enrolled fifty patients undergoing incisional hernia repair. In all patients a suction drain was placed in the subcutaneous space. In one group (FG) 4 ml fibrin glue was instilled in the subcutaneous space. In the control group (C) patients did not receive any prevention measure. Wounds fluids were collected on post-operative day 1 (POD) and once daily until drain removal. All patients were followed up by ultrasound on POD 15, 20, 40, 60. Results: Drain fluid production, even if in significantly greater amount in the C group (p 0.01) as compared with the FG group, decreased after POD 1 in both groups. Drain was removed on POD-5 in 80% of FG patients and in 36% of C patients (p 0.01). No infective or bleeding complications were detected. In group FG average hospital stay was of 5.5 ÃÂ+- 2 days versus 7.1 +- 1.5 days in group C (p 0.01). At ultrasounds examination, seroma development was similar among two groups. Conclusions: Spray instillation of fibrin glue during the surgical repair reduces amount of drained fluid and hospital stay without increasing surgical complications. However, seroma occurrence was not significantly reduced.
Original languageEnglish
Pages (from-to)767-774
Number of pages8
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Surgery


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