Durata di psicosi non trattata e consumo di cannabis in un campione di pazienti al primo episodio psicotico

Daniele La Barbera, Crocettarachele Sartorio, Laura Ferraro, Caterina La Cascia, Alessandro Bruno, Claudia Mistretta, Graziella Grillo, Lucia Sideli, Maddalena La Placa, Maria Valentina Rumeo, Marta Pomar, Roberta Grassia, Vassilij Di Giorgio, Virginia Alabastro

Research output: Contribution to conferenceOtherpeer-review


[automatically translated] Introduction: the duration of untreated psychosis (DUP) in patients with onset psychosis is a predictor of outcome and course of the disorder (Perkins, 2005). The relationship between cannabis use and DUP is still controversial. In this paper we analyzed the relationship between DUP and age of onset of cannabis use, cognitive functioning, level of education and employment status in a group of patients with psychosis onset recruited within the SGAP study (Sicilian and Genetic Psychosis) in collaboration with the Institute of Psychiatry, King's College of London. Methodology: 74 patients were recruited between the ages of 18 and 65 years to which a battery of tests consists of: Nottingham Onset Schedule (NOS-DUP) was administered, Positive and Negative Syndrome Scale (PANSS), Social Data Schedule, Cannabis Experience Questionnaire (CEQ), WAIS-R. Results: the sample, still in the process of recruitment, consists of 74 patients (M = 68.9%), mean age 26.39 (DS = 9,36). The average duration of untreated psychosis was 40.4 weeks, 39.5% of patients had used cannabis in the period immediately preceding admission. In our sample, patients who use cannabis have a shorter DUP (p = 0.023) and belong to the mental health services at an earlier age (p = 0.064) compared to non-consumers. Also there is an inverse relationship between DUP and IQ (p = 0.05). There are currently no significant correlations between DUP and severity of symptoms, assessed by the PANSS. Conclusions: Our results, in line with literature data, support the association between cannabis use and earlier onset of psychotic symptoms. In addition, the use of cannabis is associated with a lower duration of the DUP but the latter figure seems worthy of further investigation.
Original languageItalian
Number of pages2
Publication statusPublished - 2011

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