Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives

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26 Citations (Scopus)


The so-called fibrogenic cytokines, able to induce the growth of fibroblasts and their differentiation into myofibroblasts and to stimulate their production of extracellular matrix, are involved in the genesis of Dupuytren's contracture. Although many studies have been made of biomolecular aspects of palmar fibromatosis, practical applications from them are still far from imminent because of the real difficulty of blocking their action in vivo, even in a chronic, progressive lesion such as Dupuytren's disease. Consequently, surgical excision of the palmar fascia still remains the treatment of choice.
Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalJournal of Hand Surgery
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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