Drug delivery from the oral cavity: focus on a novel mechatronic delivery device

Giuseppina Campisi, Libero Italo Giannola, Thomas Velten, Axel Schumacher, Oliver A. Scholz, Oliver A. Scholz, Tomasz Ciach, Andy Wolff

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Dental drug delivery systems have been used for a long time, in particular for the local therapy of diseases affecting the oral cavity. Research today concentrates on the design of formulations to increase their retention time. Even today, however, prosthetic devices incorporating drug delivery are rarely used. Mainly, they are focused on prophylaxis and the release of antibacterial agents. However, as buccal delivery, because of its undeniable advantages, has become popular for systemic drug delivery, and prolonged well-controlled release has been identified as beneficial, especially for chronic diseases, a new class of delivery systems is evolving: highly miniaturized computerized delivery systems, integrated into a dental appliance. Dental delivery systems today are used in two ways: the main application is the local treatment of diseases affecting the oral cavity itself like periodontitis or fungal infections. The second is for systemic drug delivery.
Original languageEnglish
Pages (from-to)247-253
Number of pages7
JournalDrug Discovery Today
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery


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