Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Enrico Carmina, Pasquale Mansueto, Daniel Kort, Roger Lobo

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Abstract OBJECTIVE: To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN: Cohort. SETTING: Academic practice. PATIENT(S): A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S): Blood and ovarian ultrasound at baseline and after 5 years. MAJOR OUTCOME MEASURE(S): Serum antimüllerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound. RESULT(S): After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH ≤ 4 ng/mL was associated with ovulatory function. CONCLUSION(S): Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)1043-1046
Number of pages4
JournalFertility and Sterility
Volume98
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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