DNA-binding of zinc(II) and nickel(II) salphen-like complexes extrapolated at 1 M salt concentration: Removing the ionic strength bias in physiological conditions

Giuseppe Gennaro, Giampaolo Barone, Riccardo Bonsignore

Research output: Contribution to journalArticle

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Abstract

The DNA-binding of two salphen-like metal complexes of nickel(II) (1) and zinc(II) (2) was investigated in different ionic strength solutions by absorption spectroscopy. The data analysis allowed us to obtain the values of their extrapolated DNA-binding constant in physiological conditions, with DNA-binding strength in the order Ni > Zn, and to give relative weight to the electrostatic and non-electrostatic contributions to their DNA-interaction.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalJournal of Inorganic Biochemistry
Volume207
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Inorganic Chemistry

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