Discovery of new G-quadruplex bindingchemotypes

Gloria Di Vita, Mekala Gunaratnam, Rupesh Nanjunda, W. David Wilson, David W. Boykin, Stephen Neidle, Mohamed A. Ismail, Ingrida Pazitna, Gloria Di Vita, Ehsan Varavipour, Arvind Kumar, Arvind Kumar, Stephan A. Ohnmacht

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.
Original languageEnglish
Pages (from-to)960-963
Number of pages4
JournalChemical Communications
Volume50
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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