Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma.

Anna Calascibetta, Federico Aragona, Rosario Sanguedolce, Anna Martorana, Daniela Cabibi, Federico Aragona, Maria Campione, Anna Martorana, Anna Calascibetta, Rosario Sanguedolce, Daniela Cabibi, Maria Campione

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11 Citations (Scopus)

Abstract

Abstract. Background: Pure signet-ring cell colorectalcarcinoma (SRCC) is an infrequent and highly malignanthistological variant of colorectal cancer (CRC), while it ispresent as a histological component in colorectal carcinomasmore frequently. Materials and Methods: The aim of thiswork was to widen the knowledge of the biological factorsinvolved in the pathogenesis and aggressiveness of SRCC bythe identification and evaluation of possible molecularabnormalities. By means of immunohistochemistry theexpression of the proteolytic degradation enzyme matrixmetalloprotease (MMP)-1, that is a collagenase specificallydegrading collagens I, II, III and of the adhesion proteins Ecadherin,β-catenin and fibronectin which are usuallyinvolved in the carcinogenesis of conventional colorectaltumours was investigated. Results: SRCCs showed asignificantly greater MMP-1 expression compared to theordinary intestinal colorectal cancer (ICRC) and asignificantly reduced E-cadherin, β-catenin and fibronectinexpression. Conclusion: The biological aggressiveness andstrong metastatic behaviour of SRCC could be due to highMMP-1 and low expression of the adhesion molecules.
Original languageEnglish
Pages (from-to)4417-4422
Number of pages6
JournalAnticancer Research
Volume2009-10-13
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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