Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches

Carmela Rita Balistreri, Rosalinda Madonna, Raffaele De Caterina, Yong-Jian Geng

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Diabetic microangiopathy, including retinopathy, is characterized by abnormal growth and leakage of small blood vessels, resulting in local edema and functional impairment of the depending tissues. Mechanisms leading to the impairment of microcirculation in diabetes are multiple and still largely unclear. However, a dysregulated vascular regeneration appears to play a key role. In addition, oxidative and hyperosmolar stress, as well as the activation of inflammatory pathways triggered by advanced glycation end-products and toll-like receptors, have been recognized as key underlying events. Here, we review recent knowledge on cellular and molecular pathways of microvascular disease in diabetes. We also highlight how new insights into pathogenic mechanisms of vascular damage in diabetes may indicate new targets for prevention and treatment.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalVascular Pharmacology
Volume90
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Medicine
  • Pharmacology

Fingerprint

Dive into the research topics of 'Diabetic microangiopathy: Pathogenetic insights and novel therapeutic approaches'. Together they form a unique fingerprint.

Cite this