Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure

Gabriella Misiano, Michele Arcopinto, Carlo Vigorito, Emanuele Bobbio, Andrea Salzano, Andrea M. Isidori, Eduardo Bossone, Alberto M. Marra, Pasquale Perrone-Filardi, Antonio Cittadini, Francesco Ferrara, Francesco Giallauria, Olga Vriz, Vincenzo Triggiani, Raffaele Napoli, Francesco Saccà, Salvatore Milano

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Abstract

Inflammatory activation plays a pivotal role in chronic heart failure (CHF) through the increased expression of pro-inflammatory cytokines [1]. Decreased plasma levels of Interleukin (IL-) 5, IL-7 and Interferon-γ (IFN-γ) and increased levels of IL-9 have been already described in CHF [2], and a negative correlation was also reported between IL-9 and left ventricular ejection fraction (LVEF) [2]. Yet, there are only limited data exploring the association between cytokines and functional capacity in CHF and their prognostic role [3]; therefore, primary end-point of the current study was to evaluate all-cause mortality according to changes in cytokines plasma levels in CHF patients.  
Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalINTERNATIONAL JOURNAL OF CARDIOLOGY
Volume209
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Misiano, G., Arcopinto, M., Vigorito, C., Bobbio, E., Salzano, A., Isidori, A. M., Bossone, E., Marra, A. M., Perrone-Filardi, P., Cittadini, A., Ferrara, F., Giallauria, F., Vriz, O., Triggiani, V., Napoli, R., Saccà, F., & Milano, S. (2016). Detectable interleukin-9 plasma levels are associated with impaired cardiopulmonary functional capacity and all-cause mortality in patients with chronic heart failure. INTERNATIONAL JOURNAL OF CARDIOLOGY, 209, 114-117.