Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

Salvatrice Mancuso, Loveleen Bansi, Iuri Fanti, Mattia C.F. Prosperi, Anne-Mieke Vandamme, Kristel Van Laethem, David Dunn, Rolf Kaiser, David A.M.C. Van De Vijver, David Asboe, Ricardo Camacho, Simona Di Giambenedetto, Valeria Ghisetti, Carlo Torti, Maurizio Zazzi, Anders Sönnerborg, Andrea De Luca, Francisco M. Codoñer, Ricardo Camacho

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis. © 2013 The Author.
Original languageEnglish
Pages (from-to)1216-1220
Number of pages5
JournalTHE JOURNAL OF INFECTIOUS DISEASES
Volume207
Publication statusPublished - 2013

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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