Cytotoxic properties of Marrubium globosum ssp. libanoticum and its bioactive components

Daniela Rigano, Francesco Menichini, Filomena Conforti, Felice Senatore, Carmen Formisano, Mariangela Marrelli

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6 Citations (Scopus)

Abstract

Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae) is a medicinal plant used in Lebanon for the treatment of inflammatory diseases, asthma, coughs and other pulmonary and urinary problems. The goal of our study was to assess the biological activity of M. globosum by testing different extracts of the aerial parts for their antiproliferative activity against human melanoma cells using the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The chloroform fraction showed the greatest activity. The compounds isolated from the extracts were also tested: the mixture of (13S)-9α,13α-epoxylabda-6β(19),16(15)-diol dilactone and (13R)-9α,13α-epoxylabda-6β(19),16(15)-diol dilactone was the most active fraction, with an IC50 value of 29.2 ± 0.06 μg/mL
Original languageEnglish
Pages (from-to)567-569
Number of pages3
JournalNatural Product Communications
Volume8
Publication statusPublished - 2013
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Complementary and alternative medicine
  • Drug Discovery
  • Plant Science
  • Pharmacology

Cite this

Rigano, D., Menichini, F., Conforti, F., Senatore, F., Formisano, C., & Marrelli, M. (2013). Cytotoxic properties of Marrubium globosum ssp. libanoticum and its bioactive components. Natural Product Communications, 8, 567-569.