Cytotoxic activity of some natural and synthetic kauranes

Antonella Maria Maggio, Sergio Rosselli, Gabriella Bellone, Maurizio Bruno, Kuo-Hsiung Lee, Tzu-Hsuan Chen, Kenneth F. Bastow

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 mu M, respectively. These two 1-analogues are promising lead compounds for further investigation.
Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalJournal of Natural Products
Volume70
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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