Cytotoxic activity of some natural and synthetic guaianolides

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain
Original languageEnglish
Pages (from-to)1042-1046
Number of pages5
JournalJournal of Natural Products
Volume68
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Plant Science
  • Chemistry (miscellaneous)
  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Cytotoxic activity of some natural and synthetic guaianolides'. Together they form a unique fingerprint.

Cite this