Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides

Sergio Rosselli; Antonella Maria Maggio; Maurizio Bruno; Carlo Irace; Nicola Mascolo; Carmen Formisano; Carmen Maffettone

Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides

Sergio Rosselli, Antonella Maria Maggio, Maurizio Bruno, Carlo Irace, Nicola Mascolo, Carmen Formisano, Carmen Maffettone

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid (5), new in the literature. The cytotoxic activities of elasclepic acid (1), ent-atis-16-en-19-oic acid (2), ent-beyer-15-en-19-oic acid (3), ent-kaur-16-en-19-oic acid (4) and meoidic acid (5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

Original language	English
Pages (from-to)	1285-1287
Number of pages	3
Journal	Planta Medica
Volume	74
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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@article{a260e823f40845d48ed5046527e65d99,

title = "Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides",

abstract = "The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid (5), new in the literature. The cytotoxic activities of elasclepic acid (1), ent-atis-16-en-19-oic acid (2), ent-beyer-15-en-19-oic acid (3), ent-kaur-16-en-19-oic acid (4) and meoidic acid (5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.",

keywords = "Elaeoselinum asclepium subsp. meoides, Umbelliferae, cytotoxic activity, diterpenoids, meoidic acid, Elaeoselinum asclepium subsp. meoides, Umbelliferae, cytotoxic activity, diterpenoids, meoidic acid",

author = "Sergio Rosselli and Maggio, {Antonella Maria} and Maurizio Bruno and Carlo Irace and Nicola Mascolo and Carmen Formisano and Carmen Maffettone",

year = "2008",

language = "English",

volume = "74",

pages = "1285--1287",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

}

TY - JOUR

T1 - Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides

AU - Rosselli, Sergio

AU - Maggio, Antonella Maria

AU - Bruno, Maurizio

AU - Irace, Carlo

AU - Mascolo, Nicola

AU - Formisano, Carmen

AU - Maffettone, Carmen

PY - 2008

Y1 - 2008

N2 - The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid (5), new in the literature. The cytotoxic activities of elasclepic acid (1), ent-atis-16-en-19-oic acid (2), ent-beyer-15-en-19-oic acid (3), ent-kaur-16-en-19-oic acid (4) and meoidic acid (5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

AB - The phytochemical investigation of the acetone extract of the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori afforded several known diterpenoids as well as meoidic acid (5), new in the literature. The cytotoxic activities of elasclepic acid (1), ent-atis-16-en-19-oic acid (2), ent-beyer-15-en-19-oic acid (3), ent-kaur-16-en-19-oic acid (4) and meoidic acid (5) were investigated on rat glioma C6 cells by evaluation of cell growth inhibition.

KW - Elaeoselinum asclepium subsp. meoides

KW - Umbelliferae

KW - cytotoxic activity

KW - diterpenoids

KW - meoidic acid

KW - Elaeoselinum asclepium subsp. meoides

KW - Umbelliferae

KW - cytotoxic activity

KW - diterpenoids

KW - meoidic acid

UR - http://hdl.handle.net/10447/45451

M3 - Article

VL - 74

SP - 1285

EP - 1287

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

ER -

Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium subsp. meoides

Abstract

All Science Journal Classification (ASJC) codes

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