Abstract
Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
Original language | English |
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Pages (from-to) | 4022-4025 |
Number of pages | 4 |
Journal | Cancer Research |
Volume | 68 |
Publication status | Published - 2008 |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research