Crucial role of interleukin-4 in the survival of colon cancer stem cells

Giorgio Stassi, Matilde Todaro, Mileidys Perez Alea, Maria Giovanna Francipane, Mileidys Perez Alea, Ylenia Lombardo, Giorgio Stassi, Jan Paul Medema, Matilde Todaro

Research output: Contribution to journalArticlepeer-review

96 Citations (Scopus)

Abstract

Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
Original languageEnglish
Pages (from-to)4022-4025
Number of pages4
JournalCancer Research
Volume68
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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