Crucial role of interleukin-4 in the survival of colon cancer stem cells

Giorgio Stassi, Matilde Todaro, Mileidys Perez Alea, Maria Giovanna Francipane, Ylenia Lombardo, Giorgio Stassi, Jan Paul Medema, Matilde Todaro

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)

Abstract

Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
Original languageEnglish
Pages (from-to)4022-4025
Number of pages4
JournalCancer Research
Volume68
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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