TY - JOUR
T1 - Crucial role of interleukin-4 in the survival of colon cancer stem cells
AU - Stassi, Giorgio
AU - Todaro, Matilde
AU - Alea, Mileidys Perez
AU - Francipane, Maria Giovanna
AU - Alea, Mileidys Perez
AU - Lombardo, Ylenia
AU - Stassi, Giorgio
AU - Medema, Jan Paul
AU - Todaro, Matilde
PY - 2008
Y1 - 2008
N2 - Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
AB - Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma
UR - http://hdl.handle.net/10447/55527
M3 - Article
VL - 68
SP - 4022
EP - 4025
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
ER -