Crucial role of interleukin-4 in the survival of colon cancer stem cells

Giorgio Stassi; Matilde Todaro; Mileidys Perez Alea; Maria Giovanna Francipane; Ylenia Lombardo; Giorgio Stassi; Jan Paul Medema; Matilde Todaro

Crucial role of interleukin-4 in the survival of colon cancer stem cells

Giorgio Stassi, Matilde Todaro, Mileidys Perez Alea, Maria Giovanna Francipane, Ylenia Lombardo, Giorgio Stassi, Jan Paul Medema, Matilde Todaro

Discipline Chirurgiche, Oncologiche e Stomatologiche
Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma

Original language	English
Pages (from-to)	4022-4025
Number of pages	4
Journal	Cancer Research
Volume	68
Publication status	Published - 2008

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Crucial role of interleukin-4 in the survival of colon cancer stem cells",

abstract = "Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma",

author = "Giorgio Stassi and Matilde Todaro and Alea, {Mileidys Perez} and Francipane, {Maria Giovanna} and Ylenia Lombardo and Giorgio Stassi and Medema, {Jan Paul} and Matilde Todaro",

year = "2008",

language = "English",

volume = "68",

pages = "4022--4025",

journal = "Journal of Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

}

TY - JOUR

T1 - Crucial role of interleukin-4 in the survival of colon cancer stem cells

AU - Stassi, Giorgio

AU - Todaro, Matilde

AU - Alea, Mileidys Perez

AU - Francipane, Maria Giovanna

AU - Lombardo, Ylenia

AU - Stassi, Giorgio

AU - Medema, Jan Paul

AU - Todaro, Matilde

PY - 2008

Y1 - 2008

N2 - Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma

AB - Colon tumors may be maintained by a rare fraction of cancerstem-like cells (CSC) that express the cell surface markerCD133. Self-renewing CSCs exhibit relatively greater resistanceto clinical cytotoxic therapies and recent work suggests thatthis resistance may be mediated in part by an autocrineresponse to the immune cytokine interleukin 4 (IL-4). BlockingIL-4 signaling can sensitize CSCs to apoptotic stimuliand increase the in vivo efficacy of cytotoxic therapy. Thesefindings suggest that inhibitors of IL-4 signaling may offer anew therapeutic tool in colon carcinoma

UR - http://hdl.handle.net/10447/55527

M3 - Article

VL - 68

SP - 4022

EP - 4025

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

ER -