Critical Roles of EGFR Family Members in Breast Cancer and Breast Cancer Stem Cells: Targets for Therapy

Giuseppe Montalto, Melchiorre Cervello, Alberto M. Martelli, Joanna Dulińska-Litewka, Concettina Fenga, Timothy Fitzgerald, Saverio Candido, Ferdinando Nicoletti, Agustino Tafuri, Joerg Basecke, Agnieszka Gizak, Kvin Lertpiriyapong, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Zoya Demidenko, Aurora Scalisi, Lyudmyla Drobot, Dariusz Rakus, Sandra Marmiroli, Massimo LibraLinda S. Steelman, Piotr Laidler, James A. Mccubrey, Luca M. Neri, Michelle Milella, Lucio Cocco, Giuseppe Montalto, Matilde Y. Follo, Stephen L. Abrams

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The roles of the epidermal growth factor receptor (EGFR) signaling pathway in various cancers including breast, bladder, brain, colorectal, esophageal, gastric, head and neck, hepatocellular, lung, neuroblastoma, ovarian, pancreatic, prostate, renal and other cancers have been keenly investigated since the 1980's. While the receptors and many downstream signaling molecules have been identified and characterized, there is still much to learn about this pathway and how its deregulation can lead to cancer and how it may be differentially regulated in various cell types. Multiple inhibitors to EGFR family members have been developed and many are in clinical use. Current research often focuses on their roles and other associated pathways in cancer stem cells (CSCs), identifying sites where therapeutic resistance may develop and the mechanisms by which microRNAs (miRs) and other RNAs regulate this pathway. This review will focus on recent advances in these fields with a specific focus on breast cancer and breast CSCs. Relatively novel areas of investigation, such as treatments for other diseases (e.g., diabetes, metabolism, and intestinal parasites), have provided new information about therapeutic resistance and CSCs.
Original languageEnglish
Pages (from-to)2358-2388
Number of pages31
JournalCURRENT PHARMACEUTICAL DESIGN
Volume22
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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