Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study

Laura Maniscalco, Enzo Maria Giuseppe Cumbo, Vera Panzarella, Olga Di Fede, Giuseppina Campisi, Maria Ester Licata, Antonino Albanese, Francesca Toia, Rodolfo Mauceri, Vera Panzarella, Olga Di Fede, Rodolfo Mauceri, Giuseppina Mazzola, Laura Maniscalco, Giuseppina Campisi, Alberto Bedogni

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17 Citations (Scopus)

Abstract

Introduction. The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. Methods. We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. Results. We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. Conclusion. We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBioMed Research International
Volume2018
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry,Genetics and Molecular Biology

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