Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation

Marcello Cimador, Ettore Piro, Giovanni Corsello, Mario Giuffre, Giuseppa Pinello, Ingrid Anne Mandy Schierz

Research output: Contribution to journalArticle

Abstract

Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.
Original languageEnglish
Number of pages5
JournalEARLY HUMAN DEVELOPMENT
Publication statusPublished - 2020

Fingerprint

Somites
Medical Records
Odds Ratio
X-Rays
Newborn Infant
Phenotype

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

@article{ff28f1def4634446b4bcc9ded846e84b,
title = "Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation",
abstract = "Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95{\%} CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48{\%}),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.",
author = "Marcello Cimador and Ettore Piro and Giovanni Corsello and Mario Giuffre and Giuseppa Pinello and Schierz, {Ingrid Anne Mandy}",
year = "2020",
language = "English",
journal = "EARLY HUMAN DEVELOPMENT",
issn = "0378-3782",

}

TY - JOUR

T1 - Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation

AU - Cimador, Marcello

AU - Piro, Ettore

AU - Corsello, Giovanni

AU - Giuffre, Mario

AU - Pinello, Giuseppa

AU - Schierz, Ingrid Anne Mandy

PY - 2020

Y1 - 2020

N2 - Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.

AB - Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.

UR - http://hdl.handle.net/10447/390417

M3 - Article

JO - EARLY HUMAN DEVELOPMENT

JF - EARLY HUMAN DEVELOPMENT

SN - 0378-3782

ER -