Concomitant Small Cell Neuroendocrine Carcinoma ofGallbladder and Breast Cancer

Gaetano Giuseppe Di Vita, Anna Maria Caruso, Salvatore Buscemi, Francesco Aragona, Rosalia Patti, Valentina Territo

Research output: Contribution to journalArticle

Abstract

The neuroendocrine carcinoma is defined as a high-grade malignant neuroendocrine neoplasm arising from enterochromaffincells, usually disposed in the mucosa of gastric and respiratory tracts. The localization in the gallbladder is rare. Knowledge ofthese gallbladder tumors is limited and based on isolated case reports. We describe a case of an incidental finding of small cellneuroendocrine carcinoma of the gallbladder, observed after cholecystectomy for cholelithiasis, in a 55-year-old female, whoalready underwent quadrantectomy and sentinel lymph-node biopsy for breast cancer. The patient underwent radiotherapy forbreast cancer and six cycles of chemotherapy with cisplatin and etoposide. Eighteen months after surgery, the patient was free fromdisease. Small cell neuroendocrine carcinoma of the gallbladder has poor prognosis. Because of the rarity of the reported cases,specific prognostic factors have not been identified. The coexistence of small cell neuroendocrine carcinoma of the gallbladderwith another malignancy has been reported only once.The contemporary presence of the two neoplasms could reflect that bioactiveagents secreted by carcinoid can promote phenotypic changes in susceptible cells and induce neoplastic transformation.
Original languageEnglish
Number of pages0
JournalCASE REPORTS IN SURGERY
Volume2014
Publication statusPublished - 2014

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Neuroendocrine Carcinoma
Small Cell Carcinoma
Gallbladder
Breast Neoplasms
Neoplasms
Neoplastic Cell Transformation
Sentinel Lymph Node Biopsy
Incidental Findings
Cholelithiasis
Carcinoid Tumor
Cholecystectomy
Etoposide
Gastric Mucosa
Respiratory System
Cisplatin
Radiotherapy
Carcinoma
Drug Therapy

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Concomitant Small Cell Neuroendocrine Carcinoma ofGallbladder and Breast Cancer. / Di Vita, Gaetano Giuseppe; Caruso, Anna Maria; Buscemi, Salvatore; Aragona, Francesco; Patti, Rosalia; Territo, Valentina.

In: CASE REPORTS IN SURGERY, Vol. 2014, 2014.

Research output: Contribution to journalArticle

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AU - Di Vita, Gaetano Giuseppe

AU - Caruso, Anna Maria

AU - Buscemi, Salvatore

AU - Aragona, Francesco

AU - Patti, Rosalia

AU - Territo, Valentina

PY - 2014

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N2 - The neuroendocrine carcinoma is defined as a high-grade malignant neuroendocrine neoplasm arising from enterochromaffincells, usually disposed in the mucosa of gastric and respiratory tracts. The localization in the gallbladder is rare. Knowledge ofthese gallbladder tumors is limited and based on isolated case reports. We describe a case of an incidental finding of small cellneuroendocrine carcinoma of the gallbladder, observed after cholecystectomy for cholelithiasis, in a 55-year-old female, whoalready underwent quadrantectomy and sentinel lymph-node biopsy for breast cancer. The patient underwent radiotherapy forbreast cancer and six cycles of chemotherapy with cisplatin and etoposide. Eighteen months after surgery, the patient was free fromdisease. Small cell neuroendocrine carcinoma of the gallbladder has poor prognosis. Because of the rarity of the reported cases,specific prognostic factors have not been identified. The coexistence of small cell neuroendocrine carcinoma of the gallbladderwith another malignancy has been reported only once.The contemporary presence of the two neoplasms could reflect that bioactiveagents secreted by carcinoid can promote phenotypic changes in susceptible cells and induce neoplastic transformation.

AB - The neuroendocrine carcinoma is defined as a high-grade malignant neuroendocrine neoplasm arising from enterochromaffincells, usually disposed in the mucosa of gastric and respiratory tracts. The localization in the gallbladder is rare. Knowledge ofthese gallbladder tumors is limited and based on isolated case reports. We describe a case of an incidental finding of small cellneuroendocrine carcinoma of the gallbladder, observed after cholecystectomy for cholelithiasis, in a 55-year-old female, whoalready underwent quadrantectomy and sentinel lymph-node biopsy for breast cancer. The patient underwent radiotherapy forbreast cancer and six cycles of chemotherapy with cisplatin and etoposide. Eighteen months after surgery, the patient was free fromdisease. Small cell neuroendocrine carcinoma of the gallbladder has poor prognosis. Because of the rarity of the reported cases,specific prognostic factors have not been identified. The coexistence of small cell neuroendocrine carcinoma of the gallbladderwith another malignancy has been reported only once.The contemporary presence of the two neoplasms could reflect that bioactiveagents secreted by carcinoid can promote phenotypic changes in susceptible cells and induce neoplastic transformation.

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