Abstract

[automatically translated] Alzheimer's Disease is a key challenge of the twenty-first century public health. The therapies currently used for the treatment of AD are based on symptomatic aspects of the disease [1]. An important role in disease is played by Heat shock proteins (HSPs), proteins that govern the control of protein folding [2]. Recently, it was shown that HSP60 mediates translocation of the Amyloid Precursor Protein (APP) and the peptide Amyloid beta (Abeta) in the mitochondria, leading to the loss of dell'organulo function [3]. In the field of the approaches of potential therapies, curcumin is emerging as a lead compound for the development of neuro-protective drugs [4]. Here we will present our recent studies on the effect of curcumin and curcumin-like compounds on an in vitro model of neuronal cells. In particular, we will present the results related to the synthesis of some curcumin-like compounds and ability to interfere on the expression of HSP60.
Original languageItalian
Number of pages1
Publication statusPublished - 2014

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