Complexes of diorganotin(IV) with aminoacids and a dipeptide. Synthesis and structural investigations.

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Abstract

The aim of this work is to synthesize complexes of Arginine, effector of recognition,with organotin(IV) ions (R2Sn2+, R =Me, nBu) which are known to possess antitumour, antimicrobial, anti-inflammatory activities.The complexes were investigated by FT-IR and 119Sn Můssbauer.While identical stoichiometriesare present for Me2Sn(Arg)2 and Me2Sn(Boc-Arg)2 complexes, 119Sn Můssbauerspectra give a clear evidence of different coordination modes.L-Arginine appears to behave as a chelating ligand through carboxylate and a-NH2groups in the former, while in Nα-Boc-L-Arginine complex, the Nα-protected amino groupbeing exempted from coordination, only the carboxylate groups are effectors of bonding tothe organometallic moieties.The L-Ala-L-Arg dipeptide complex appears to adopt a trigonal-bipyramidal geometryat tin, the organometallic moiety being coordinated by α-amino, deprotonated peptidenitrogen and terminal carboxylate groups. FT-IR spectra give a clear indication that guanidinogroups in all the complexes are not involved in coordination, since ν(C=N-H) frequencyof the terminal guanidino group is fairly constant and unshifted relative to the free ligand.
Original languageEnglish
Pages (from-to)129-138
Number of pages10
JournalATTI DELLA ACCADEMIA DI SCIENZE, LETTERE E ARTI DI PALERMO, PARTE PRIMA: SCIENZE
VolumeSerieQuinta/Volume XXIV
Publication statusPublished - 2008

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