Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas

Francesco Agnello, Massimo Midiri, Ludovico La Grutta, Roberto Lagalla, Massimo Galia, Domenico Albano, Umberto Ficola, Caterina Patti, Giorgio Cannizzaro, Antonino Mulè, Emanuele Grassedonio

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Abstract

Objectives To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas. Methods 68 patients (37 males, 31 females; median age 42 years; range 15-86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen's k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic ITER using also bone marrow and available biopsies if clinically indicated. Results The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2%). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6%), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1%). The differences between the stages were more frequent in the patients with Mantle cell lymphoma. Conclusions WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.
Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalEuropean Journal of Radiology
Volume85
Publication statusPublished - 2016

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Diffusion Magnetic Resonance Imaging
Lymphoma
Mantle-Cell Lymphoma
Hodgkin Disease
B-Lymphocytes
Bone Marrow
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas. / Agnello, Francesco; Midiri, Massimo; La Grutta, Ludovico; Lagalla, Roberto; Galia, Massimo; Albano, Domenico; Ficola, Umberto; Patti, Caterina; Cannizzaro, Giorgio; Mulè, Antonino; Grassedonio, Emanuele.

In: European Journal of Radiology, Vol. 85, 2016, p. 313-318.

Research output: Contribution to journalArticle

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abstract = "Objectives To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas. Methods 68 patients (37 males, 31 females; median age 42 years; range 15-86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen's k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic ITER using also bone marrow and available biopsies if clinically indicated. Results The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2{\%}). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6{\%}), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1{\%}). The differences between the stages were more frequent in the patients with Mantle cell lymphoma. Conclusions WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.",
author = "Francesco Agnello and Massimo Midiri and {La Grutta}, Ludovico and Roberto Lagalla and Massimo Galia and Domenico Albano and Umberto Ficola and Caterina Patti and Giorgio Cannizzaro and Antonino Mul{\`e} and Emanuele Grassedonio",
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T1 - Comparison between whole-body MRI with diffusion-weighted imaging and PET/CT in staging newly diagnosed FDG-avid lymphomas

AU - Agnello, Francesco

AU - Midiri, Massimo

AU - La Grutta, Ludovico

AU - Lagalla, Roberto

AU - Galia, Massimo

AU - Albano, Domenico

AU - Ficola, Umberto

AU - Patti, Caterina

AU - Cannizzaro, Giorgio

AU - Mulè, Antonino

AU - Grassedonio, Emanuele

PY - 2016

Y1 - 2016

N2 - Objectives To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas. Methods 68 patients (37 males, 31 females; median age 42 years; range 15-86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen's k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic ITER using also bone marrow and available biopsies if clinically indicated. Results The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2%). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6%), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1%). The differences between the stages were more frequent in the patients with Mantle cell lymphoma. Conclusions WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.

AB - Objectives To compare whole body-MRI (WB-MRI) with diffusion-weighted imaging and FDG-PET/CT in staging newly diagnosed FDG-avid lymphomas. Methods 68 patients (37 males, 31 females; median age 42 years; range 15-86 years) with histologically confirmed lymphoma (37 Classical Hodgkin, 16 Diffuse large B-cell, 10 Follicular, 5 Mantle cell) underwent both MRI and FDG-PET/CT before treatment. Ann Arbor stages obtained with WB-MRI and FDG-PET/CT were compared using Cohen's k statistics. Moreover WB-MRI and FDG-PET/CT stages were compared with the pathological stages obtained after the diagnostic ITER using also bone marrow and available biopsies if clinically indicated. Results The agreement between WB-MRI and FDG-PET/CT was excellent. WB-MRI stage was equal to those of FDG-PET/CT in 62/68 patients (91.2%). There was an excellent agreement between WB-MRI stage and pathological stage (63/68 patients; 92.6%), and between FDG-PET/CT and pathological stage (64/68 patients; 94.1%). The differences between the stages were more frequent in the patients with Mantle cell lymphoma. Conclusions WB-MRI can be considered as a promising technique for FDG-avid lymphoma staging.

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