Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test

Salvatore Battaglia, Nicola Scichilone, Alida Benfante, Stefania Principe, Amelia Grosso, Federica Albicini, Erica Gini, Stefania Principe, Angelo Guido Corsico, Ilaria Rita Piccionello, Marta Amata

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

COVID-19 modified the healthcare system. Nasal-pharyngeal swab (NPS), with real-time reverse transcriptase-polymerase (PCR), is the gold standard for the diagnosis; however, there are difficulties related to the procedure that may postpone it. The study aims to evaluate whether other elements than the PCR-NPS are reliable and confirm the diagnosis of COVID-19. This is a cross-sectional study on data from the Lung Unit of Pavia (confirmed) and at the Emergency Unit of Palermo (suspected). COVID-19 was confirmed by positive NPS, suspected tested negative. We compared clinical, laboratory and radiological variables and performed Logistic regression to estimate which variables increased the risk of COVID-19. The derived ROC-AUCcurve, assessed the accuracy of the model to distinguish between COVID-19 suspected and confirmed. We selected 50 confirmed and 103 suspected cases. High Reactive C-Protein (OR: 1.02; CI95%: 0.11–1.02), suggestive CT-images (OR: 11.43; CI95%: 3.01–43.3), dyspnea (OR: 10.48; CI95%: 2.08–52.7) and respiratory failure (OR: 5.84; CI95%: 1.73–19.75) increased the risk of COVID-19, whereas pleural effusion decreased the risk (OR: 0.15; CI95%: 0.04–0.63). ROC confirmed the discriminative role of these variables between suspected and confirmed COVID-19 (AUC 0.91). Clinical, laboratory and imaging features predict the diagnosis of COVID-19, independently from the NPS result.
Original languageEnglish
Number of pages8
JournalJournal of Clinical Medicine
Volume11
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • General Medicine

Fingerprint

Dive into the research topics of 'Comparison between Suspected and Confirmed COVID-19 Respiratory Patients: What Is beyond the PCR Test'. Together they form a unique fingerprint.

Cite this