COMPARAZIONE DELLE RELAZIONI DI DIFFERENTI DEFINIZIONI DI SINDROME METABOLICA CON L'IPERTROFIA VENTRICOLARE SX NELL'IPERTENSIONE ESSENZIALE

Emilio Nardi, Calogero Geraci, Giuseppe Mule', Santina Cottone, Paola Cusimano, Giovanni Cerasola, Alessandro Palermo, Giovanna Bonanno, Miriam Costanzo

Research output: Contribution to conferenceOther

Abstract

[automatically translated] Numerous studies have shown that the metabolic syndrome (MS), when it is defined according to the criteria dell'ATPIII, both when defined according to the IDF criteria, is associated with an increase in the mass of the left ventricle (LV). However, it is not known whether these two different definitions of MS have the same ability to identify the LV hypertrophy (LVH). Furthermore, one of the criticisms of the concept of MS is related to the fact of being a dichotomous variable, thereby limiting the ability to define the severity of the cardiovascular risk in the individual patient. The aim of our study was to comparatively evaluate the ability of different definitions of MS to identify LVH in a large group of essential hypertension. They studied 724 hypertensive patients without diabetes (mean age 45.3 ± 11.7 years; 63% male), free of cardiovascular complications. All subjects were submitted, in the absence of anti-hypertensive drug treatment, assay of biochemical parameters in routine, in detection of the anthropometric parameters, in ambulatory blood pressure monitoring of 24 hours and to echocardiographic examination. 4 were adopted definitions of MS, 2 dichotomous (ATPIII and IDF) and 2 "quantitative", referred to as a calculated average value of Z sex-specific score of each component ( "SM Z score"), and another obtained as the average of percentage changes from the cut-off established by ATPIII criteria ( "delta%" SM). The areas under the ROC curves for each definition of MS, for the presence of LVH (= LV mass indexed for altezza2.7> 51 g / M2.7), were higher for the SM Z score (0.645 ± 0.023) and for the SM delta% (0.636 ± 0.023), in comparison both with the definition dell'ATPIII (0.597 ± 0.023) (respectively, p = 0.008 and p = 0.02), both in the IDF (0574 ± 0023) (respectively, p = 0.001 and p = 0.008). In multiple logistic regression models stepwise the IVS, after adjusting for various confounding factors, it was associated more closely to the quantitative definitions of MS (p <0.0001 for the Z score SM and P = 0.007 for the delta% SM), than to dicomotiche definitions of MS (p = 0.01 and p = 0.03 for ATPIII for IDF) our results suggest that in patients with hypertension l '
Original languageItalian
Pages147-147
Number of pages1
Publication statusPublished - 2009

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