Combination chemotherapy of 5-Fluorouracil, Epidoxorubicin and Mitomicin C in the palliative treatment of locally-advanced and/or metastatic adenocarcinoma of the stomach.

Guido Bajardi, Calogero Cipolla, Mario Latteri, Vittorio Gebbia, Nicola Gebbia, Vittorio Gebbia, Curto, Pischedda, Matteo Florena, Valenza, Mastrandrea, Cannata, Calogero Cipolla, Bajardi, Mario A. Latteri, Testa

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Abstract

Thirty-seven consecutive patients with advanced and/or metastatic gastric adenocarcinoma received a combination of 5-fluorouracil 600 mg/m2 on days 1, 8, 29, 36; epidoxorubicin 75 mg/m2 i.v. on days 1, 29; mitomycin C 10 mg/m2 i.v. on day 1. This cycle was repeated every 8 weeks. Out of a total of 34 evaluable patients, 2 (5.8%) had a complete response and 7 (20.6%) had a partial response with an overall median duration of 40 weeks (range 20-128). The median survival of responding patients was not reached after a mean follow-up of 76 weeks, while that of patients with no change and progressive disease was reached at 36 and 13 weeks respectively. Treatment was generally well tolerated with hematological and gastrointestinal toxicities being the major side-effects. Despite the use of epidoxorubicin 75 mg/m2, the 26.4% (95% confidence limits 16-36%) objective response rate is not satisfactory. Evaluation of more aggressive protocols is strongly recommended within the limits of controlled trials.
Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Chemotherapy
Volume6
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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