COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS

Francesca Rappa, Angelo Leone, Francesco Carini, Giovanni Tomasello, Rosalyn Jurjus, Tarek Bou-Assi, Alice Gerges Geagea, Sahar Al Kattar, Margherita Mazzola, Abdo Jurjus

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38 Citations (Scopus)

Abstract

One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanism. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documentes the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yeld definitive results and were performed mostly in vitro on cell population, or in vivo in experimental animal models.
Original languageEnglish
Pages (from-to)4759-4766
Number of pages8
JournalAnticancer Research
Volume37
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Rappa, F., Leone, A., Carini, F., Tomasello, G., Jurjus, R., Bou-Assi, T., Geagea, A. G., Al Kattar, S., Mazzola, M., & Jurjus, A. (2017). COLORECTAL CARCINOGENESIS; ROLE OF OXIDATIVE STRESS AND ANTIOXIDANTS. Anticancer Research, 37, 4759-4766.