Colonizzazione pneumococcica in bambini in eta' scolare e possibile trasmissione intrafamiliare: l'esperienza dello studio "BINOCOLO" in Sicilia.

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Abstract

[automatically translated] INTRODUCTION The oropharyngeal colonization of pneumococcal covers 90% of children in the first year of life and the family contacts can play a crucial role in the same. To analyze the factors associated with pneumococcal colonization and possible intra-family transmission was realized BINOCULARS project: "Children with their grandparents against pneumococcus" on a student population and related co-resident family. METHODS For the enrollment of study participants, two primary schools of the Municipality of Palermo have been identified. For every subject recruited, a questionnaire and an oropharyngeal swab were collected through a suitably trained healthcare team. Research and serotyping of Streptococcus pneumoniae were conducted using molecular analysis in real-time PCR. RESULTS In the study were enrolled 36 families of students, for a total of 110 individuals co-resident. The 86% of the students had received at least one dose of vaccine against pneumococcal (compared to 2% of the family members> 12 years). Among the main factors associated to colonization by pneumococcus have been identified: the presence of a less than 4 rooms per dwelling (p = 0.05), smoking more than 15 cigarettes / day (p = 0.078), having carried out or not the pneumococcal vaccination (p = 0.77). The distribution of the identified serotypes is shown in Figure 1. CONCLUSIONS This paper identifies some of the potential socio-demographic and behavioral determinants correlated to the spread of pneumococcal colonization in the family. Results obtained, as statistically not significant due to the limited sample size, confirm the findings in other experiments carried out in different contexts. The study made it possible to standardize the Methods to be applied in the future on a larger series can consolidate the preliminary Results obtained so far.
Original languageItalian
Number of pages1
Publication statusPublished - 2016

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