Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.

Giuseppina Campisi, Antonio Craxi, Antonio Carroccio, Domenico Compilato, Scully, Lorenzo Lo Muzio, L. Lo Lo Muzio, Procaccini, Giuseppe Iacono, Carlo Catassi

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

AIMS:Oral mucosal lesions may be markers of chronic gastrointestinal disorders, such as those causing malabsorption. Our objectives were to assess the prevalence of recurrent oral aphthous-like ulcers in coeliac disease patients living in the Mediterranean area, and to evaluate the impact of a gluten-free diet.METHODS:A test group of 269 patients (age range 3-17 years) with coeliac disease confirmed both serologically and histologically was compared with a control group of 575 otherwise clinically healthy subjects for the presence, or a positive history of aphthous-like ulcers. Coeliac disease patients with aphthous-like ulcers were re-evaluated 1-year after starting a gluten-free diet.RESULTS:Aphthous-like ulcers were found significantly more frequently in coeliac disease, in 22.7% (61/269) of patients with coeliac disease versus 7.1% (41/575) of controls (p=<0.0001; chi-square=41.687; odds ratio=4.3123; 95% confidence interval=2.7664:6.722). Most coeliac disease patients with aphthous-like ulcers and adhering strictly to gluten-free diet (71.7%; 33/46) reported significant improvement on gluten-free diet, with no or reduced episodes of aphthous-like ulcers (p=0.0003; chi-square=13.101; odds ratio=24.67; 95% confidence interval=2.63:231.441).CONCLUSIONS:The epidemiological association found between coeliac disease and aphthous-like ulcers suggests that recurrent aphthous-like ulcers should be considered a risk indicator for coeliac disease, and that gluten-free diet leads to ulcer amelioration.
Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalDigestive and Liver Disease
Volume40
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.'. Together they form a unique fingerprint.

Cite this