Clinical Use of κ Free Light Chains Index as a Screening Test for Multiple Sclerosis

Luisa Agnello, Marcello Ciaccio, Giulia Bivona, Giuseppe Salemi, Bruna Lo Sasso, Concetta Scazzone, Emanuela Maria Pappalardo, Francesco Meli, Rosalia Caldarella

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2 Citations (Scopus)


Objective: To assess the usefulness of the κ free light chain index(κFLCi) as a screening test to identify patients with suspected MS.Methods: The study included 56 patients with a request to test foroligoclonal bands (OCBs). OCBs were detected by isoelectric focusing,followed by immunofixation. Cerebrospinal fluid (CSF) and serum κFLCwere measured by a turbidimetric assay. Also, the κFLC index (κFLCi)was calculated.Results: CSF κFLC levels and κFLCi were significantly higher in patientswith multiple sclerosis (MS) than in patients with other neurologicaldiseases (NDs; P < .001 and P < .001, respectively). At the cutoff valueof 2.9, the κFLCi detected MS with sensitivity of 97% and specificity of65%. Overall, 92% patients with κFLCi of 2.9 or greater and who hadtested positive for OCBs were diagnosed as having MS.Conclusion: Our findings support the use of κFLCi as a screening testwhen MS is suspected, followed by OCB detection as a confirmatory test
Original languageEnglish
Number of pages6
JournalLaboratory Medicine
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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