Clinical observations and risk factors for tinnitus in a Sicilian cohort

Pietro Salvago, Emanuele Cannizzaro, Enrico Martines, Fulvio Plescia, Francesco Martines, Francesco Martines, Federico Sireci, Marianna Mucia

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The aims of this study were to determine thedistribution of risk factors associated with tinnitus analysingtheir role in the development of tinnitus and the effectsof their interaction; to evidence the importance of a suitableand adequate clinical and audiologic assessment toavoid those modifiable risk factors responsible for cochleardysfunction and tinnitus onset. 46 subjects with tinnitusand 74 controls were studied according to: age, sex, BodyMass Index (BMI), neck circumference, tobacco smoking,feeling fatigue or headache, self reporting snoring, hypertension,diabetes, coronary heart disease, and/or hyperlipidemia,and laboratory finding as lipid profile and levels ofreactive oxygen metabolites (d-ROM). Audiologicalassessment was performed by multi-frequency audiometry(PTA0.5–16 kHz) and transient-evoked otoacoustic emissions(TEOAE diagnostic). Univariate analysis was performed toexamine the association between determinants andoccurrence of tinnitus; Mantel–Haenszel test (G.or) wasused to investigate the joint effect of determinants on tinnitus.Tinnitus was more frequent among males with age[50 years; BMI[30 kg/m2, neck circumference[40 cm,headache, hypertension, hypercholesterolemia resultedsignificant risk factors for tinnitus (P.0001). Tinnitusgroup had more comorbidity (P.0001) and worseaudiometric thresholds (60.87 Vs 21.62 % hearing loss;P.0001) with respect to control group. The interactionbetween hypertension–BMI C 30 kg/m2 (G.or = 8.45) andsmoking–hypercholesterolemia (G.or = 5.08) increasesthe risk of tinnitus (P.0001). Our results underline thatseveral factors either individually or jointly contribute totinnitus onset; a comprehensive knowledge about tinnitusrisk factors and associated clinical conditions could contributeto minimizing this disorder.
Original languageEnglish
Pages (from-to)2719-2729
Number of pages11
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume272
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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