Background: Parkinson’s disease (PD) is characterized by motor deficits which may not completelyrespond to the dopaminergic therapy, thus posing a therapeutic challenge. Non-invasive brainstimulation techniques such as transcranial direct current stimulation (tDCS) have shown promisingresults as possible alternative of treatment in different neurological disorders including PD. Thetherapeutic effect of tDCS, which may increase (anodal currents) or decrease (cathodal currents) thecortical excitability level, likely relies on modulation of cortico-subcortical interactions andabnormal patterns of cortical activation.Objective: To investigate safety and therapeutic potential of different montages of tDCS in PDpatients with asymmetric motor symptoms.Patients and methods: Patients with asymmetric PD were recruited. While on-treatment,participants underwent 7 separate experimental sessions. The tDCS was applied with the followingdifferent electrode montages: anodal and cathodal stimulation of the primary motor cortex (M1)contralateral to the more affected body side, anodal and cathodal stimulation of M1 contralateral tothe less affected body side, and sham-stimulation. We evaluated the clinical effects on motorfunction by means of the MDS-UPDRS, by evaluation of bradykinesia of the arms and by the fingertapping test. All experiments were performed according to a double-blinded design. Thedopaminergic medication was continued in all subjects throughout the course of the experiment.Results: 16 patients (8M/8F) were included (aged 58±11.5 years). Compared to baseline and shamstimulation, the motor performances improved in both hands after anodal tDCS of M1 contralateralto the more affected body side. Also the cathodal stimulation of M1 contralateral to the less affectedbody side was shown to improve the motor performances.Conclusions: Our results confirm the therapeutic potential of tDCS in PD patients, providing usefulinformation on which is the best tDCS montage to apply as a treatment option.
|Number of pages||1|
|Publication status||Published - 2016|