Clinical course of ulcerative colitis

Mario Cottone, Mario Cottone, Civitavecchia, Filippo Mocciaro, Scimeca, Giovanni Perricone, Ambrogio Orlando, Daniela Scimeca, Giuseppe Civitavecchia

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. Dig Liver Dis. 2008 Jul;40 Suppl 2:S247-52.Clinical course of ulcerative colitis.Cottone M, Scimeca D, Mocciaro F, Civitavecchia G, Perricone G, Orlando A.Department of Medicine, Pneumology and Nutrition Clinic, V. Cervello Hospital,University of Palermo, Palermo, Italy.AIM: To provide a review of studies on prognosis in ulcerative colitis byreviewing the relevant population-based cohort studies. On the basis of incidenceand population studies, ulcerative colitis has a favourable clinical course, withgood quality of life, a chronic course characterized by at least one relapse, anda surgery rate of 30% after 10 years from diagnosis. Patients affected by severe ulcerative colitis have a higher risk of colectomy, and some clinical variablesmay predict the disease's clinical course. Most patients respond to steroids and only a low percentage become dependent, or non-responders to steroids. Patientswho have a long-lasting ulcerative colitis (>10 years) or are affected by anextensive disease have an increased risk of developing colorectal cancer, whilethose treated with immunosuppressants for long period of time may have anincreased risk of developing lymphomas. Data on mortality in ulcerative colitispatients are not homogeneous, but if a real risk exists it is in patients withextensive or severe disease. The evidence that patients with severe ulcerativecolitis are often non-smokers may explain why in one study the mortality rate waslower.
Original languageEnglish
Pages (from-to)247-252
JournalDigestive Diseases and Sciences
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Cottone, M., Cottone, M., Civitavecchia, Mocciaro, F., Scimeca, Perricone, G., Orlando, A., Scimeca, D., & Civitavecchia, G. (2008). Clinical course of ulcerative colitis. Digestive Diseases and Sciences, 40, 247-252.