Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial

Antonio Cascio, Claudia Colomba, Lucina Titone Lanza Di Scalea, Claudia Colomba, Lucina Titone, Spinello Antinori, Antonio Cascio, David L. Paterson

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54 Citations (Scopus)

Abstract

We conducted an open-label randomized controlled trial to compare the efficacy and safety of clarithromycin (15/mg/kg/day in 2 divided doses for 7 days) with those of azithromycin (10 mg/kg/day in 1 dose for 3 days) in the treatment of children with Mediterranean spotted fever. Until now, there has not been a gold-standard therapy for this rickettsial disease in children. Eighty-seven children were randomized to receive 1 of the 2 drugs. The mean time to defervescence (+/- standard deviation) was 46.2+/-36.4 h in the clarithromycin group and 39.3+/-31.3 h in the azithromycin group. These differences were not statistically significant and both drugs were equally well-tolerated. Clarithromycin and azithromycin could be acceptable therapeutic alternatives to chloramphenicol and tetracyclines for children aged < or =8 years with Mediterranean spotted fever. Azithromycin, because it has a long half-life, offers the advantages of administration in a single daily dose and a shorter duration of therapy, which could increase compliance in children
Original languageEnglish
Pages (from-to)154-158
Number of pages5
JournalClinical Infectious Diseases
Volume34
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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