Citotoxic Saponins from Schefflera rotundifolia

Fabio Venturella, Nunziatina De Tommasi, Francesco De Simone, Alessandra Braca, Stefania Marzocco, Giuseppina Autore, Ivano Morelli

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents
Original languageEnglish
Pages (from-to)960-966
JournalPlanta Medica
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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