Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease

Research output: Contribution to journalArticle


Purpose: To evaluate circulating irisin levels in patients with active and controlled Cushing’sdisease (CD).Design: Forty-four patients with CD evaluated during the active phase and after 12 monthsof biochemical remission and 40 controls were recruited.Methods: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulinsensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oraldisposition index and circulating irisin levels were evaluated.Results: Patients with active CD showed lower irisin levels compared to controls (p<0.001) andcontrolled CD (p<0.001). The independent variables significantly associated with irisin werewaist circumference (WC) (p=0.025), body fat percentage (BF%) (p=0.009), PTH (p=0.007) andchair rising test (CRT) (p<0.001) in active CD and WC (p=0.013), BF% (p=0.014), PTH(p=0.038), CRT (p=0.029) and urinary-free cortisol (p<0.001) in controlled CD.Conclusion: Circulating irisin levels tend to be lower in patients with active CD comparedto those with controlled CD and controls. They are strongly associated with osteosarcopeniaand central obesity in CD and therefore may be a possible marker of diagnosis
Original languageEnglish
Pages (from-to)1565-1574
Number of pages10
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Pharmacology

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