Circulating IL-6 and sIL-6R in patients with hepatocellular carcinoma

Maurizio Soresi, Natale D'Alessandro, Giuseppe Montalto, Lydia Giannitrapani, Melchiorre Cervello, La Rosa, Virruso, Marzia La Rosa, Lucrezia Virruso

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Interleukin-6 plays a central role in regulating the immune system, hematopoiesis, and acute phase reaction. It interacts with a receptor complex consisting of a specific ligand-binding protein (IL-6R, gp80) and a signal transduction protein (gp130). In this report, serum levels of IL-6 and a soluble form of the interleukin-6 receptor (sIL-6R) were evaluated in patients with hepatocellular carcinoma. The correlation between IL-6 and sIL-6R values, the stage of hepatocellular carcinoma, and main liver function tests was also studied.
Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalAnnals of the New York Academy of Sciences
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • History and Philosophy of Science


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